Current projects in the Travin Lab
1. Tiarins - new Trojan-Horse inhibitors of aminoacyl-tRNA synthetases.
D. Y. Travin#, A.Livensky, D. Bikmetov, C. Pavlov, M. Serebryakova, K. Gilep, F-J. Wu, D. Naquin, T. Timchenko, G . Lippens, S. Zirah, P. Mergaert, and S. Dubiley#, “Tiarins, a diverse family of natural Trojan-horse aminoacyl-tRNA synthetase inhibitors discovered by genome mining”, bioRxiv preprint (# - corresponding authors)
2. Mechanisms of action of "abandoned" natural products targeting the bacterial ribosome.
D. Y. Travin*,#, R. S. Basu*, M. N. Paranjpe, D. Klepacki, A. I. Zhurakovskaya, N. Vázquez-Laslop, A. S. Mankin, Y. S. Polikanov#, and M. G. Gagnon#, “Sequence-specific trapping of EF-Tu/glycyl-tRNA complex on the ribosome by bottromycin”, bioRxiv preprint (* - authors contributed equally, # - corresponding authors)